GMS 6140 – Principles of Immunology

Spring 2020

Lectures:  Mon/Wed/Fri, 10:40-11:30 a.m., room R2-265 (ARB)
Application Sessions:  Tuesdays, 9:35-11:30 a.m., room R2-265

(Schedule subject to change)

Mon, Jan 6         Course Overview, Immunology History
Tue, Jan 7          TBL:  Basic Concepts in Immunology
Wed, Jan 8         Basic Principles of Immunity
Fri, Jan 10          Ig Structure/Function and Ag-Ab Interactions
Mon, Jan 13       Generation of Receptor Diversity
Tue, Jan 14        TBL:  Antibody Diversity
Wed, Jan 15       Lymphoid Tissues and Organs
Fri, Jan 17          The Innate Immune System
Mon, Jan 20       No Class – MLK Holiday
Tue, Jan 21        TNF & IFN Cytokines (10:40-11:30)
Wed, Jan 22      Complement
Fri, Jan 24          Cells of the Innate Immune System
Mon, Jan 27       Pattern Recognition by Innate Immunity
Tue, Jan 28        TBL:  Innate Immunity
Wed, Jan 29       NK and ILC Development
Fri, Jan 31           Introduction to Immunogenetics & MHC
Mon, Feb 3          T Lymphocyte Receptors
Tue, Feb 4          TBL:  T Cell Receptors
Wed, Feb 5         The MHC and its Proteins
Fri, Feb 7            Antigen Processing and Presentation
Mon, Feb 10       Evolution of the Immune System
Tue, Feb 11        TBL:  Ag Processing/Presentation
Wed, Feb 12       Review Session
Wed, Feb 12       Exam 1 (7:00-10:00 pm, room TBA)

Fri, Feb 14          B Cell Receptors, Signaling, & Activation
Mon, Feb 17       B Lymphocyte Development
Tue, Feb 18        No class
Wed, Feb 19      B Lymphocyte Responses
Fri, Feb 21         Somatic Diversification of Ab Responses
Mon, Feb 24      Dendritic Cells
Tue, Feb 25       TBL:  Humoral Immunity
Wed, Feb 26      T Lymphocyte Development
Fri, Feb 28         T Cell Signaling Mechanisms
Mar 2-6              No Classes – Spring Break
Mon, Mar 9        T Helper Cells and Their Roles
Tue, Mar 10       Paper:  T Cell-Mediated Immunity & Development
Wed, Mar 11      CD8 T Cell Responses
Fri, Mar 13         Immunological Memory
Mon, Mar 16      Other T Cell Populations
Tue, Mar 17       Paper:  T Cell-Mediated Immunity
Wed, Mar 18      Immune Tolerance & Reg/Suppressor T Cells
Fri, Mar 20         Integration of Innate & Adaptive Immunity
Mon, Mar 23      Review Session
Tue, Mar 24       TBL:  Integration of Innate & Adaptive Immunity
Wed, Mar 25      Exam 2 (7:00-10:00 pm, room TBA)

Wed, Mar 25      Autoimmunity 1
Fri, Mar 27         Autoimmunity 2
Mon, Mar 30      Autoimmunity 3
Tue, Mar 31       TBL:  Autoimmunity
Wed, Apr 1        Evasion & Subversion of Immune Defenses
Fri, Apr 3           Immunology of HIV Infection
Mon, Apr 6        Inborn Errors of Immunity
Tue, Apr 7         TBL:  Immunodeficiencies
Wed, Apr 8        Allergy & Allergic Diseases
Fri, Apr 10         Mucosal Immunity 1
Mon, Apr 13      Mucosal Immunity 2
Tue, Apr 14       Paper:  Mucosal Immunology
Wed, Apr 15      Transplantation Immunology
Fri, Apr 17         Treatment of Unwanted Immune Responses
Mon, Apr 20      Vaccines
Tue, Apr 21        Manipulation of Immune Responses
Wed, Apr 22      Cancer Immunology
Mon, Apr 27       Exam 3 (9:00 am – 12:00 noon, room TBA)

Catalog Description

Fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. (4 credits)

Course Overview

This course focuses on fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. It is required as a core course for PhD students in the Immunology & Microbiology concentration of the biomedical sciences PhD program. This course is open to other UF graduate students with consent of the course director. Weekly small group sessions (Tuesdays) will provide students with experience in problem-solving, application of immunology principles in an experimental context, and integration of immunology & microbiology, via team-based learning and/or paper discussions.

Course Objectives

Successful will be expected to accomplish the following learning objectives.

1. Attain a working knowledge of current immunological principles related to:
    a. cell surface molecules and receptors on cells of the immune system;
b. how immune cells develop and acquire the ability to recognize antigens;
c. how immune cells interact in order to defend the body against microbes, including both innate and adaptive immunity;
d. how immune cells malfunction in autoimmunity and immunodeficiency; and
e. how the immune system may be manipulated to improve health.

2. Be able to read and discuss research papers from the current research literature in order to become familiar with experimental protocols, and develop skills in interpreting immunological data, critique of experimental designs, and formulation of new hypotheses.

3. Interpret immunological data.

4. Design immunological experiments to test a given hypothesis.

Course Material

Handouts, PowerPoint presentations, and other course material will be posted at an Canvas web site (login with Gatorlink ID and password).  All registered students will automatically be enrolled at the site during the first week of classes.

The following textbook is REQUIRED for Spring 2020:

“Janeway’s Immunobiology” by Kenneth Murphy & Casey Weaver, Garland Science, 9th Edition


(Note:  the book “Case Studies in Immunology – A Clinical Companion” was required in 2018, but will NOT be required in 2019)


Preparation for Team-Based Learning (TBL) Sessions

Teams will be set up at the beginning of the semester, and will work together throughout the semester.  Your assignment before each TBL session is to review the assigned reading, lecture presentation, and your notes relevant to the topic of that session.

Session schedule:
9:35 am – Individual Readiness Assurance Test
9:50 am – Team Readiness Assurance Test
10:05 am – Team Application Exercise – Team discussion of case studies and questions, followed by class discussion
11:30 am – Adjourn
Readiness Assurance Tests will consist of up to 10 multiple-choice questions (closed book) based on the material you have studied for that session.  Individual Readiness Assurance Tests will be completed individually, and answers will be collected using an answer sheet that is provided.  Team Readiness Assurance Tests (closed book) will consist of the same questions as the Individual Readiness Assurance Test, and team answers will be recorded on scratch-off cards that will be provided.  It is important to arrive on time!  You will not be given extra time for the individual test if you are late.


The final course grade will be based on an average of three exams (75%) and your average scores on the TBL readiness assurance test (25%)Final  grade cut-offs will be based on the final class score distribution. They will be set no higher than the following, and may be adjusted lower depending on the final score distribution.  Final % score A 90%-100%; A- 85%-89%; B+ 80%-84%; B 75%-79%; B- 70%-74%; C+ 65%-69%; C 60%-64%; C- 55%-59%.  Letter grades will affect student grade point averages according to UF grading policies.

Academic Honesty

Students are expected to act in accordance with the University of Florida policy on academic integrity (see Student Conduct Code, the Graduate Student Handbook or these web sites for more details:

Cheating, lying, misrepresentation, or plagiarism in any form is unacceptable and inexcusable behavior, and will result in a score of zero for the assignment and reporting to the UF Dean of Students Office.  We, the members of the University of Florida community, pledge to hold ourselves and our peers to the highest standards of honesty and integrity.

Class Attendance

Students are expected to read all assignments prior to class, and to be prepared to attend and participate in all sessions. Personal issues with respect to class attendance or participation will be handled on an individual basis.

Exam or Other Work Make-up

Make-up assignments will be provided for excused absences from paper discussions and team-based learning sessions, and must be completed by mutually agreed upon dates. Alternate dates will be arranged for exams with excused absences or extenuating circumstances (e.g., child care issues in the evening).

Accommodations for Students with Disabilities

Students with disabilities requesting accommodations should first register with the Disability Resource Center (352-392-8565, by providing appropriate documentation. Once registered, students will receive an accommodation letter which must be presented to the instructor when requesting accommodations. Students with disabilities should follow this procedure as early as possible in the semester.

Counseling and Student Health

Students may occasionally have personal issues that arise in the course of pursuing higher education or that may interfere with their academic performance. If you find yourself facing problems affecting your coursework, you are encouraged to talk with an instructor and to seek confidential assistance at the UF Counseling & Wellness Center, 352-392-1575. Visit their web site for more information: (, see also link therein for Emergency Assistance). Crisis intervention is always available 24/7 from the Alachua County Crisis Center at (352) 264-6789. Do not wait until you reach a crisis to come in and talk with us. We have helped many students through stressful situations impacting their academic performance. You are not alone, so do not be afraid to ask for assistance.