GMS 6140 – Principles of Immunology

Spring 2021

Lectures:  Mon/Wed/Fri, 10:40-11:30 a.m., via Zoom
Application Sessions:  Tuesdays, 9:35-11:30 a.m., via Zoom

PART ONE – Cells, Receptors, and Innate Immunity
Mon, Jan 11     Course Overview & A Brief History
Tue, Jan 12      TBL:  Basic Concepts in Immunology
Wed, Jan 13     Ig Structure/Function and Ag-Ab Interactions
Fri, Jan 15        Generation of Receptor Diversity
Mon, Jan 18     No Class – MLK Holiday
Tue, Jan 19      TBL:  Antibody Diversity
Wed, Jan 20     Hematopoiesis and Lymphoid Organs
Fri, Jan 22        The Innate Immune System
Mon, Jan 25     TNF & IFN Cytokines
Tue, Jan 26      TBL:  Innate Immunity 1
Wed, Jan 27     Complement
Fri, Jan 29        Cells of the Innate Immune System
Mon, Feb 1       Pattern Recognition by Innate Immunity
Tue, Feb 2       TBL:  Innate Immunity 2
Wed, Feb 3      Natural Killer Cells and Innate Lymphoid Cells
Fri, Feb 5         Introduction to Immunogenetics & MHC
Mon, Feb 8      T Lymphocyte Receptors
Tue, Feb 9       TBL:  T Cell Receptors
Wed, Feb 10    The MHC and its Proteins
Fri, Feb 12       Antigen Processing and Presentation
Mon, Feb 15    Evolution of the Immune System
Tue, Feb 16     TBL:  Ag Processing/Presentation
Wed, Feb 17    Review Session
Wed, Feb 17    Exam 1 available online in Canvas for 24 hours beginning at 5:00 pm

PART TWO – Humoral and Cell-Mediated Immunity
Fri, Feb 19       B Cell Receptors, Signaling, & Activation
Mon, Feb 22    B Lymphocyte Development
Tue, Feb 23     No class
Wed, Feb 24    B Lymphocyte Responses
Fri, Feb 26       Somatic Diversification of Ab Responses
Mon, Mar 1      Dendritic Cells
Tue, Mar 2       TBL:  Humoral Immunity
Wed, Mar 3      T Lymphocyte Development
Fri, Mar 5          T Cell Signaling Mechanisms
Mon, Mar 8       T Helper Cells and Their Roles
Tue, Mar 9        TBL:  T Cell Development
Wed, Mar 10     CD8 T Cell Responses
Fri, Mar 12         Other T Cell Populations
Mon, Mar 15      Immune Tolerance & Reg/Suppressor T Cells
Tue, Mar 16       TBL:  T Cell-Mediated Immunity
Wed, Mar 17      Immunological Memory
Fri, Mar 19         Integration of Innate & Adaptive Immunity
Mon, Mar 22      Review Session
Tue, Mar 23       TBL:  Memory & Integration of Innate & Adaptive Immunity
Tue, Mar 23       Exam 2 available online in Canvas for 24 hours beginning at 5:00 pm

PART THREE – Immune Responses in Health & Disease
Wed, Mar 24     Mucosal Immunity 1
Fri, Mar 26        Mucosal Immunity 2
Mon, Mar 29     Evasion & Subversion of Immune Defenses
Tue, Mar 30      Paper:  Mucosal Immunology
Wed, Mar 31    Immunology of HIV Infection
Fri, Apr 2          Inborn Errors of Immunity
Mon, Apr 5        Allergy & Allergic Diseases
Tue, Apr 6         TBL:  Immunodeficiencies & Allergy
Wed, Apr 7        Autoimmunity 1
Fri, Apr 9           Autoimmunity 2
Mon, Apr 12      Autoimmunity 3
Tue, Apr 13       TBL:  Autoimmunity
Wed, Apr 14      Transplantation Immunology
Fri, Apr 16         Treatment of Unwanted Immune Responses
Mon, Apr 19      Vaccines
Tue, Apr 20       Manipulation of Immune Responses
Wed, Apr 21      Cancer Immunology
Mon, Apr 26      Exam 3 available online in Canvas for 24 hours beginning at 8:00 am

Catalog Description

Fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. (4 credits)

Course Overview

This course focuses on fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. It is required as a core course for PhD students in the Immunology & Microbiology concentration of the biomedical sciences PhD program. This course is open to other UF graduate students with consent of the course director. Weekly small group sessions (Tuesdays) will provide students with experience in problem-solving, application of immunology principles in an experimental context, and integration of immunology & microbiology, via team-based learning and/or paper discussions.

Course Objectives

Successful will be expected to accomplish the following learning objectives.

1. Attain a working knowledge of current immunological principles related to:
    a. cell surface molecules and receptors on cells of the immune system;
b. how immune cells develop and acquire the ability to recognize antigens;
c. how immune cells interact in order to defend the body against microbes, including both innate and adaptive immunity;
d. how immune cells malfunction in autoimmunity and immunodeficiency; and
e. how the immune system may be manipulated to improve health.

2. Be able to read and discuss research papers from the current research literature in order to become familiar with experimental protocols, and develop skills in interpreting immunological data, critique of experimental designs, and formulation of new hypotheses.

3. Interpret immunological data.

4. Design immunological experiments to test a given hypothesis.

Course Material

Handouts, PowerPoint presentations, and other course material will be posted at an Canvas web site (login with Gatorlink ID and password).  All registered students will automatically be enrolled at the site during the first week of classes.

The following textbook is REQUIRED for Spring 2021:

“Janeway’s Immunobiology” by Kenneth Murphy & Casey Weaver, Garland Science, 9th Edition




Preparation for Team-Based Learning (TBL) Sessions

Teams will be set up at the beginning of the semester, and will work together throughout the semester.  Your assignment before each TBL session is to review the assigned reading, lecture presentation, and your notes relevant to the topic of that session.

Session schedule:
9:35 am – Individual Readiness Assurance Test
9:50 am – Team Readiness Assurance Test
10:05 am – Team Application Exercise – Team discussion of case studies and questions, followed by class discussion
11:30 am – Adjourn
Readiness Assurance Tests will consist of up to 10 multiple-choice questions (closed book) based on the material you have studied for that session.  Individual Readiness Assurance Tests will be completed individually, and answers will be collected using an answer sheet that is provided.  Team Readiness Assurance Tests (closed book) will consist of the same questions as the Individual Readiness Assurance Test, and team answers will be recorded on scratch-off cards that will be provided.  It is important to arrive on time!  You will not be given extra time for the individual test if you are late.


The final course grade will be based on an average of three exams (75%) and your average scores on the TBL readiness assurance test (25%)Final  grade cut-offs will be based on the final class score distribution. They will be set no higher than the following, and may be adjusted lower depending on the final score distribution.  Final % score A 90%-100%; A- 85%-89%; B+ 80%-84%; B 75%-79%; B- 70%-74%; C+ 65%-69%; C 60%-64%; C- 55%-59%.  Letter grades will affect student grade point averages according to UF grading policies.

Academic Honesty

Students are expected to act in accordance with the University of Florida policy on academic integrity (see Student Conduct Code, the Graduate Student Handbook or these web sites for more details:

Cheating, lying, misrepresentation, or plagiarism in any form is unacceptable and inexcusable behavior, and will result in a score of zero for the assignment and reporting to the UF Dean of Students Office.  We, the members of the University of Florida community, pledge to hold ourselves and our peers to the highest standards of honesty and integrity.

Class Attendance

Students are expected to read all assignments prior to class, and to be prepared to attend and participate in all sessions. Personal issues with respect to class attendance or participation will be handled on an individual basis.

Exam or Other Work Make-up

Make-up assignments will be provided for excused absences from paper discussions and team-based learning sessions, and must be completed by mutually agreed upon dates. Alternate dates will be arranged for exams with excused absences or extenuating circumstances (e.g., child care issues in the evening).

Accommodations for Students with Disabilities

Students with disabilities requesting accommodations should first register with the Disability Resource Center (352-392-8565, by providing appropriate documentation. Once registered, students will receive an accommodation letter which must be presented to the instructor when requesting accommodations. Students with disabilities should follow this procedure as early as possible in the semester.

Counseling and Student Health

Students may occasionally have personal issues that arise in the course of pursuing higher education or that may interfere with their academic performance. If you find yourself facing problems affecting your coursework, you are encouraged to talk with an instructor and to seek confidential assistance at the UF Counseling & Wellness Center, 352-392-1575. Visit their web site for more information: (, see also link therein for Emergency Assistance). Crisis intervention is always available 24/7 from the Alachua County Crisis Center at (352) 264-6789. Do not wait until you reach a crisis to come in and talk with us. We have helped many students through stressful situations impacting their academic performance. You are not alone, so do not be afraid to ask for assistance.