GMS 6140 – Principles of Immunology

Spring 2023

Lectures:  Mon/Wed/Fri, 10:40-11:30 am, R2-265 (Academic Research Building)
Application Sessions:  Tuesdays, 9:35-11:30 am, R2-265

PART ONE – Cells, Receptors, and Innate Immunity
Mon, Jan 9        Course Overview, Immunology History
Wed, Jan 11       Basic Principles of Immunity
Fri, Jan 13          Hematopoiesis and Lymphoid Organs
Mon, Jan 16       No Class – MLK Holiday
Tue, Jan 17         TBL:  Basic Concepts of Immunity
Wed, Jan 18       The Innate Immune System
Fri, Jan 20          TNF & IFN Cytokines
Mon, Jan 23       Complement
Tue, Jan 24         TBL:  Innate Immunity
Wed, Jan 25        Cells of the Innate Immune System
Fri, Jan 27           Pattern Recognition by Innate Immunity
Mon, Jan 30        Natural Killer Cells and Innate Lymphoid Cells
Tue, Jan 31          TBL:  Innate Immunity
Wed, Feb 1           Ig Structure/Function and Ag-Ab Interactions
Fri, Feb 3             Generation of Receptor Diversity
Mon, Feb 6          Introduction to Immunogenetics & MHC
Tue, Feb 7            TBL:  Antibody Diversity
Wed, Feb 8          T Lymphocyte Receptors
Fri, Feb 10           The MHC and its Proteins
Mon, Feb 13        Antigen Processing and Presentation
Tue, Feb 14          TBL:  T Cell Receptors & Ag Presentation
Wed, Feb 15         Evolution of the Immune System
Fri, Feb 17            Review Session All faculty
Tue, Feb 21          Exam 1 available online in Canvas (Honorlock) for 24 hours beginning at 7:00 am

PART TWO – Humoral and Cell-Mediated Immunity
Mon, Feb 20       B Cell Receptors, Signaling, & Activation
Tue, Feb 21         No class (Exam 1)
Wed, Feb 22       B Lymphocyte Development
Fri, Feb 24          B Lymphocyte Responses
Mon, Feb 27       Somatic Diversification of Ab Responses
Tue, Feb 28         TBL:  Humoral Immunity
Wed, Mar 1         Dendritic Cells
Fri, Mar 3            T Lymphocyte Development
Mon, Mar 6         T Cell Signaling Mechanisms
Tue, Mar 7           TBL:  T Cell Development
Wed, Mar 8         T Helper Cells and Their Roles
Fri, Mar 10           CD8 T Cell Responses
Mon, Mar 20       Other T Cell Populations
Tue, Mar 21         TBL:  T Cell-Mediated Immunity
Wed, Mar 22       Immune Tolerance & Reg/Suppressor T Cells
Fri, Mar 24          Immunological Memory
Mon, Mar 27       Integration of Innate & Adaptive Immunity
Tue, Mar 28        TBL:  Memory & Integration of Innate & Adaptive Immunity
Thu, Mar 30        Exam 2 available online in Canvas (Honorlock) for 24 hours beginning at 7:00 am

PART THREE – Immune Responses in Health & Disease
Wed, Mar 29      Mucosal Immunity 1
Fri, Mar 31          Mucosal Immunity 2
Mon, Apr 3         Evasion & Subversion of Immune Defenses
Tue, Apr 4           Paper Discussion – Mucosal Immunity
Wed, Apr 5          Inborn Errors of Immunity
Fri, Apr 7             Immunology of HIV Infection
Mon, Apr 10        Allergy & Allergic Diseases
Tue, Apr 11          TBL:  Failures of Host Defense
Wed, Apr 12        Autoimmunity 1
Fri, Apr 14           Autoimmunity 2
Mon, Apr 17        Autoimmunity 3
Tue, Apr 18         TBL:  Autoimmunity
Wed, Apr 19        Cancer Immunology
Fri, Apr 21           Treatment of Unwanted Immune Responses
Mon, Apr 24        Vaccines
Tue, Apr 25         Manipulation of Immune Responses (9:35 lecture)
Tue, Apr 25         Transplantation Immunology (10:40 lecture)
Wed, Apr 26        Review Session
Mon, May 1          Exam 3 available online in Canvas (Honorlock) for 24 hours beginning at 7:00 am

Catalog Description

Fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. (4 credits)

Course Overview

This course focuses on fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. It is required as a core course for PhD students in the Immunology & Microbiology concentration of the biomedical sciences PhD program. This course is open to other UF graduate students with consent of the course director. Weekly small group sessions (Tuesdays) will provide students with experience in problem-solving, application of immunology principles in an experimental context, and integration of immunology & microbiology, via team-based learning and/or paper discussions.

Course Objectives

Successful will be expected to accomplish the following learning objectives.

1. Attain a working knowledge of current immunological principles related to:
    a. cell surface molecules and receptors on cells of the immune system;
b. how immune cells develop and acquire the ability to recognize antigens;
c. how immune cells interact in order to defend the body against microbes, including both innate and adaptive immunity;
d. how immune cells malfunction in autoimmunity and immunodeficiency; and
e. how the immune system may be manipulated to improve health.

2. Be able to read and discuss research papers from the current research literature in order to become familiar with experimental protocols, and develop skills in interpreting immunological data, critique of experimental designs, and formulation of new hypotheses.

3. Interpret immunological data.

4. Design immunological experiments to test a given hypothesis.

Course Material

Handouts, PowerPoint presentations, and other course material will be posted at an Canvas web site (login with Gatorlink ID and password).  All registered students will automatically be enrolled at the site during the first week of classes.

The following textbook is REQUIRED for Spring 2023:

NEW “Janeway’s Immunobiology” 10th Edition, by Kenneth Murphy, Casey Weaver, and Leslie Berg, 2022, W.W. Norton


Book cover


Preparation for Team-Based Learning (TBL) Sessions

Teams will be set up at the beginning of the semester, and will work together throughout the semester.  Your assignment before each TBL session is to review the assigned reading, lecture presentation, and your notes relevant to the topic of that session.

Session schedule:
9:35 am – Individual Readiness Assurance Test
9:50 am – Team Readiness Assurance Test
10:05 am – Team Application Exercise – Team discussion of case studies and questions, followed by class discussion
11:30 am – Adjourn
Readiness Assurance Tests will consist of up to 10 multiple-choice questions (closed book) based on the material you have studied for that session.  Individual Readiness Assurance Tests will be completed individually, and answers will be collected using an answer sheet that is provided.  Team Readiness Assurance Tests (closed book) will consist of the same questions as the Individual Readiness Assurance Test, and team answers will be recorded on scratch-off cards that will be provided.  It is important to arrive on time!  You will not be given extra time for the individual test if you are late.


The final course grade will be based on an average of three exams (75%) and your average scores on the TBL readiness assurance test (25%)Final  grade cut-offs will be based on the final class score distribution. They will be set no higher than the following, and may be adjusted lower depending on the final score distribution.  Final % score A 90%-100%; A- 85%-89%; B+ 80%-84%; B 75%-79%; B- 70%-74%; C+ 65%-69%; C 60%-64%; C- 55%-59%.  Letter grades will affect student grade point averages according to UF grading policies. 

Academic Honesty

Students are expected to act in accordance with the University of Florida policy on academic integrity (see Student Conduct Code, the Graduate Student Handbook or these web sites for more details:

Cheating, lying, misrepresentation, or plagiarism in any form is unacceptable and inexcusable behavior, and will result in a score of zero for the assignment and reporting to the UF Dean of Students Office.  We, the members of the University of Florida community, pledge to hold ourselves and our peers to the highest standards of honesty and integrity.

Class Attendance

Students are expected to read all assignments prior to class, and to be prepared to attend and participate in all sessions. Personal issues with respect to class attendance or participation will be handled on an individual basis.

Exam or Other Work Make-up

Make-up assignments will be provided for excused absences from paper discussions and team-based learning sessions, and must be completed by mutually agreed upon dates. Alternate dates will be arranged for exams with excused absences or extenuating circumstances (e.g., child care issues in the evening).

Accommodations for Students with Disabilities

Students with disabilities requesting accommodations should first register with the Disability Resource Center (352-392-8565, by providing appropriate documentation. Once registered, students will receive an accommodation letter which must be presented to the instructor when requesting accommodations. Students with disabilities should follow this procedure as early as possible in the semester.

Counseling and Student Health

Students may occasionally have personal issues that arise in the course of pursuing higher education or that may interfere with their academic performance. If you find yourself facing problems affecting your coursework, you are encouraged to talk with an instructor and to seek confidential assistance at the UF Counseling & Wellness Center, 352-392-1575. Visit their web site for more information: (, see also link therein for Emergency Assistance). Crisis intervention is always available 24/7 from the Alachua County Crisis Center at (352) 264-6789. Do not wait until you reach a crisis to come in and talk with us. We have helped many students through stressful situations impacting their academic performance. You are not alone, so do not be afraid to ask for assistance.