GMS 6140 – Principles of Immunology

Spring 2017

Mon/Wed/Fri, 10:40-11:30 a.m., room R2-265, Academic Research Building
Tue, 9:35-11:30 a.m., room 1101, HPNP Building

Course Directors:  Wayne T. McCormack, PhD (e-mail mccormac at ufl.edu;  phone 294-8334;  office CG-72K)
Mark A. Wallet, PhD (email mawallet at pathology.ufl.edu);  phone 273-8164;  office D6-18A)

The schedule for Spring 2017 is still being finalized, so a few changes are possible.  A final syllabus will be available at the beginning of the Spring semester.

DATE            TOPICS

Wed, Jan 4    Course Overview, Immunology History
Fri, Jan 6       Basic Principles of Immunity
Mon, Jan 9    Lymphoid Tissues and Organs
Tue, Jan 10   Application: Basic Concepts in Immunology
Wed, Jan 11  The Innate Immune System
Fri, Jan 13     Complement
Mon, Jan 16   No Class – MLK Holiday
Tue, Jan 17    Application: APCs/Innate Immunity
Wed, Jan 18   Cells of the Innate Immune System
Fri, Jan 20      Pattern Recognition by Innate Immunity
Mon, Jan 23   Induced Innate Responses to Infection
Tue, Jan 24    Application: NK and NKT Cells
Wed, Jan 25   Ig Structure/Function and Ag-Ab Interactions
Fri, Jan 27      Generation of Receptor Diversity
Mon, Jan 30   Introduction to Immunogenetics & MHC
Tue, Jan 31    Application: Ig/TCR Receptor Diversity
Wed, Feb 1     T Lymphocyte Receptors
Fri, Feb 3        The MHC and its Proteins
Mon, Feb 6     Antigen Processing and Presentation
Tue, Feb 7      Application: Ag Processing/Presentation
Wed, Feb 8     Evolution of the Immune System
Thu, Feb 9      Exam 1  (7:00-10:00 pm, room TBA)

Fri, Feb 10      T Signaling Mechanisms
Mon, Feb 13   B Cell Receptors, Signaling, & Activation
Tue, Feb 14    Application: Lymphocyte Activation & Signaling
Wed, Feb 15   B Lymphocyte Development
Fri, Feb 17      T Lymphocyte Development
Mon, Feb 20   B Lymphocyte Responses
Tue, Feb 21    Application: Humoral Immunity
Wed, Feb 22   Somatic Diversification of Ab Responses
Fri, Feb 24      Dendritic Cells
Mon, Feb 27   T Cell-Mediated Immunity 1
Tue, Feb 28    Application: T Cell-Mediated Immunity 1
Wed, Mar 1     T Cell-Mediated Immunity 2
Fri, Mar 3        FcR in Immune Regulation and Inflammation
Mar 6-10         No Classes – Spring Break
Mon, Mar 13   Integration of Innate & Adaptive Immunity
Tue, Mar 14    Application: T Cell-Mediated Immunity 2
Wed, Mar 15   Cytokines & Chemokines
Fri, Mar 17      Immune Tolerance & Reg/Suppressor T Cells
Mon, Mar 20   Immunological Memory
Tue, Mar 21    Application: Immunological Memory
Thu, Mar 23    Exam 2  (7:00-10:00 pm, room TBA)

Wed, Mar 22   Mucosal Immunity 1
Fri, Mar 24      Mucosal Immunity 2
Mon, Mar 27   Inborn Errors of Immunity
Tue, Mar 28    Application: Mucosal Immunology
Wed, Mar 29   Evasion & Subversion of Immune Defenses
Fri, Mar 31      Immunology of HIV Infection
Mon, Apr 3      Allergy & Allergic Diseases
Tue, Apr 4       Application: Hypersensitivity
Wed, Apr 5      Organ-Specific Autoimmunity
Fri, Apr 7         Systemic Autoimmunity
Mon, Apr 10    Genetic & Environmental Basis of Autoimmunity
Tue, Apr 11      Application: Autoimmunity
Wed, Apr 12    Transplantation Immunology
Fri, Apr 14       Treatment of Unwanted Immune Responses
Mon, Apr 17     Vaccines
Tue, Apr 18      Application: Manipulation of Immune Responses
Wed, Apr 19    Cancer Immunology
Mon, Apr 24     Exam 3  (9:00 am – 12:00 noon, room TBA)

Catalog Description

Fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. (4 credits)

Course Overview

This course focuses on fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. It is required as a core course for PhD students in the Immunology & Microbiology concentration of the biomedical sciences PhD program, and is taught concurrently with the course GMS 6121, Infectious Disease. This course is open to other UF graduate students with consent of the course director. Weekly small group sessions (1-2 hours each) will provide students with experience in problem-solving, application of immunology principles in an experimental context, and integration of immunology & microbiology, via team-based learning and/or paper discussions.

Course Objectives

Successful will be expected to accomplish the following learning objectives.

1. Attain a working knowledge of current immunological principles related to:

a. cell surface molecules and receptors on cells of the immune system;

b. how immune cells develop and acquire the ability to recognize antigens;

c. how immune cells interact in order to defend the body against microbes, including both innate and adaptive immunity;

d. how immune cells malfunction in autoimmunity and immunodeficiency; and

e. how the immune system may be manipulated to improve health.

2. Be able to read and discuss research papers from the current research literature in order to become familiar with experimental protocols, and develop skills in interpreting immunological data, critique of experimental designs, and formulation of new hypotheses.

3. Interpret immunological data.

4. Design immunological experiments to test a given hypothesis.

Course Material

Handouts, PowerPoint presentations, and other course material will be posted at an Canvas web site (login with Gatorlink ID and password).  All registered students will automatically be enrolled at the site during the first week of classes.

The following two textbooks are required for Spring 2017:

Janeway’s Immunobiology, by Kenneth Murphy & Casey Weaver, Garland Science, 9th Edition

Case Studies in Immunology – A Clinical Companion, by Raif Geha & Luigi Notarangelo, Garland Science, 7th Edition


janeway9clincompanion
 

Grading

The final course grade will be determined by performance on all 3 exams, in team-based learning sessions, and participation in paper discussions.    Exams 1-3 25% each = 75%;  TBL = 25%.    Final  grade cut-offs will be based on the final class score distribution. They will be set no higher than the following, and may be adjusted lower depending on the final score distribution.   Final % score A 90%-100%; A- 85%-89%; B+ 80%-84%; B 75%-79%; B- 70%-74%; C+ 65%-69%; C 60%-64%; C- 55%-59%.  Letter grades will affect student grade point averages according to UF grading policies.
https://catalog.ufl.edu/ugrad/current/regulations/info/grades.aspx

Academic Honesty

Students are expected to act in accordance with the University of Florida policy on academic integrity (see Student Conduct Code, the Graduate Student Handbook or these web sites for more details:  https://www.dso.ufl.edu/sccr/process/student-conduct-honor-code/     http://graduateschool.ufl.edu/admissions/orientation/academic-expectations/

Cheating, lying, misrepresentation, or plagiarism in any form is unacceptable and inexcusable behavior, and will result in a score of zero for the assignment and reporting to the UF Dean of Students Office.  We, the members of the University of Florida community, pledge to hold ourselves and our peers to the highest standards of honesty and integrity.

Class Attendance

Students are expected to read all assignments prior to class, and to be prepared to attend and participate in all sessions. Personal issues with respect to class attendance or participation will be handled on an individual basis.

Exam or Other Work Make-up

Make-up assignments will be provided for excused absences from paper discussions and team-based learning sessions, and must be completed by mutually agreed upon dates. Alternate dates will be arranged for exams with excused absences or extenuating circumstances (e.g., child care issues in the evening).

Accommodations for Students with Disabilities

Students with disabilities requesting accommodations should first register with the Disability Resource Center (352-392-8565, www.dso.ufl.edu/drc/) by providing appropriate documentation. Once registered, students will receive an accommodation letter which must be presented to the instructor when requesting accommodations. Students with disabilities should follow this procedure as early as possible in the semester.

Counseling and Student Health

Students may occasionally have personal issues that arise in the course of pursuing higher education or that may interfere with their academic performance. If you find yourself facing problems affecting your coursework, you are encouraged to talk with an instructor and to seek confidential assistance at the UF Counseling & Wellness Center, 352-392-1575. Visit their web site for more information: (http://www.counseling.ufl.edu/cwc/, see also link therein for Emergency Assistance). Crisis intervention is always available 24/7 from the Alachua County Crisis Center at (352) 264-6789. Do not wait until you reach a crisis to come in and talk with us. We have helped many students through stressful situations impacting their academic performance. You are not alone, so do not be afraid to ask for assistance.