GMS 6140 – Principles of Immunology
Mon/Wed/Fri, 10:40-11:30 a.m., room TBA
Tue, 9:35-11:30 a.m., room TBA
Course Directors: Wayne T. McCormack, PhD (e-mail mccormac at ufl.edu; phone 294-8334; office CG-72K)
Mark A. Wallet, PhD (email mawallet at pathology.ufl.edu); phone 273-8164; office J-583)
The schedule for Spring 2018 is still being finalized, but the basic schedule will be similar to this.
Mon, Jan 8 Course Overview, Immunology History
Tue, Jan 9 Appl: Basic Concepts in Immunology
Wed, Jan 10 Basic Principles of Immunity
Fri, Jan 12 Ig Structure/Function and Ag-Ab Interactions
Mon, Jan 15 No Class – MLK Holiday
Tue, Jan 16 Appl: TBA
Wed, Jan 17 Generation of Receptor Diversity
Fri, Jan 19 Lymphoid Tissues and Organs
Mon, Jan 22 The Innate Immune System
Tue, Jan 23 Appl: APCs/Innate Immunity
Wed, Jan 24 Complement
Fri, Jan 26 Cells of the Innate Immune System
Mon, Jan 29 Pattern Recognition by Innate Immunity
Tue, Jan 30 Appl: APCs/Innate Immunity
Wed, Jan 31 Induced Innate Responses to Infection
Fri, Feb 2 NK and NKT Cells
Mon, Feb 5 Introduction to Immunogenetics & MHC
Tue, Feb 6 Appl: APCs/Innate Immunity
Wed, Feb 7 T Lymphocyte Receptors
Fri, Feb 9 The MHC and its Proteins
Mon, Feb 12 Antigen Processing and Presentation
Tue, Feb 13 Appl: Ag Processing/Presentation
Wed, Feb 14 Evolution of the Immune System
Thu, Feb 15 Exam 1 (7:00-10:00 pm, room TBA)
Fri, Feb 16 T Signaling Mechanisms
Mon, Feb 19 B Cell Receptors, Signaling, & Activation
Tue, Feb 20 Appl: Lymphocyte Activation & Signaling
Wed, Feb 21 B Lymphocyte Development
Fri, Feb 23 B Lymphocyte Responses
Mon, Feb 26 Somatic Diversification of Ab Responses
Tue, Feb 27 Appl: Humoral Immunity
Wed, Feb 28 Dendritic Cells
Fri, Mar 2 T Lymphocyte Development
Mar 5-9 No Classes – Spring Break
Mon, Mar 12 T Cell-Mediated Immunity 1
Tue, Mar 13 Appl: T Cell-Mediated Immunity 1
Wed, Mar 14 T Cell-Mediated Immunity 2
Fri, Mar 16 T Cell Cytokines
Mon, Mar 19 Integration of Innate & Adaptive Immunity
Tue, Mar 20 Appl: T Cell-Mediated Immunity 2
Wed, Mar 21 TNF & IFN Cytokines
Fri, Mar 23 Immune Tolerance & Reg/Suppressor T Cells
Mon, Mar 26 Immunological Memory
Tue, Mar 27 Appl: Immunological Memory
Thu, Mar 29 Exam 2 (7:00-10:00 pm, room TBA)
Wed, Mar 2 Mucosal Immunity 1
Fri, Mar 30 Mucosal Immunity 2
Mon, Apr 2 Inborn Errors of Immunity
Tue, Apr 3 Appl: Mucosal Immunology
Wed, Apr 4 Evasion & Subversion of Immune Defenses
Fri, Apr 6 Immunology of HIV Infection
Mon, Apr 9 Allergy & Allergic Diseases
Tue, Apr 10 Appl: Hypersensitivity
Wed, Apr 11 Organ-Specific Autoimmunity
Fri, Apr 13 Systemic Autoimmunity
Mon, Apr 16 Genetic & Environmental Basis of Autoimmunity
Tue, Apr 17 Appl: Autoimmunity
Wed, Apr 18 Transplantation Immunology
Fri, Apr 20 Treatment of Unwanted Immune Responses
Mon, Apr 23 Vaccines
Tue, Apr 24 Manipulation of Immune Responses
Wed, Apr 25 Cancer Immunology
Mon, Apr 30 Exam 3 (9:00 am – 12:00 noon, room TBA)
Fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. (4 credits)
This course focuses on fundamental principles of basic and experimental immunology, from first engagement of innate immunity to the generation of the adaptive immune response and its clinical consequences. It is required as a core course for PhD students in the Immunology & Microbiology concentration of the biomedical sciences PhD program, and is taught concurrently with the course GMS 6121, Infectious Disease. This course is open to other UF graduate students with consent of the course director. Weekly small group sessions (1-2 hours each) will provide students with experience in problem-solving, application of immunology principles in an experimental context, and integration of immunology & microbiology, via team-based learning and/or paper discussions.
Successful will be expected to accomplish the following learning objectives.
1. Attain a working knowledge of current immunological principles related to:
a. cell surface molecules and receptors on cells of the immune system;
b. how immune cells develop and acquire the ability to recognize antigens;
c. how immune cells interact in order to defend the body against microbes, including both innate and adaptive immunity;
d. how immune cells malfunction in autoimmunity and immunodeficiency; and
e. how the immune system may be manipulated to improve health.
2. Be able to read and discuss research papers from the current research literature in order to become familiar with experimental protocols, and develop skills in interpreting immunological data, critique of experimental designs, and formulation of new hypotheses.
3. Interpret immunological data.
4. Design immunological experiments to test a given hypothesis.
Handouts, PowerPoint presentations, and other course material will be posted at an Canvas web site (login with Gatorlink ID and password). All registered students will automatically be enrolled at the site during the first week of classes.
Janeway’s Immunobiology, by Kenneth Murphy & Casey Weaver, Garland Science, 9th Edition Case Studies in Immunology – A Clinical Companion, by Raif Geha & Luigi Notarangelo, Garland Science, 7th Edition
Janeway’s Immunobiology, by Kenneth Murphy & Casey Weaver, Garland Science, 9th Edition
Case Studies in Immunology – A Clinical Companion, by Raif Geha & Luigi Notarangelo, Garland Science, 7th Edition
The final course grade will be based on an average of three exams. Final grade cut-offs will be based on the final class score distribution. They will be set no higher than the following, and may be adjusted lower depending on the final score distribution. Final % score A 90%-100%; A- 85%-89%; B+ 80%-84%; B 75%-79%; B- 70%-74%; C+ 65%-69%; C 60%-64%; C- 55%-59%. Letter grades will affect student grade point averages according to UF grading policies.
Students are expected to act in accordance with the University of Florida policy on academic integrity (see Student Conduct Code, the Graduate Student Handbook or these web sites for more details: https://sccr.dso.ufl.edu/students/student-conduct-code/ http://graduateschool.ufl.edu/admissions/orientation/academic-expectations/
Cheating, lying, misrepresentation, or plagiarism in any form is unacceptable and inexcusable behavior, and will result in a score of zero for the assignment and reporting to the UF Dean of Students Office. We, the members of the University of Florida community, pledge to hold ourselves and our peers to the highest standards of honesty and integrity.
Students are expected to read all assignments prior to class, and to be prepared to attend and participate in all sessions. Personal issues with respect to class attendance or participation will be handled on an individual basis.
Exam or Other Work Make-up
Make-up assignments will be provided for excused absences from paper discussions and team-based learning sessions, and must be completed by mutually agreed upon dates. Alternate dates will be arranged for exams with excused absences or extenuating circumstances (e.g., child care issues in the evening).
Accommodations for Students with Disabilities
Students with disabilities requesting accommodations should first register with the Disability Resource Center (352-392-8565, www.dso.ufl.edu/drc/) by providing appropriate documentation. Once registered, students will receive an accommodation letter which must be presented to the instructor when requesting accommodations. Students with disabilities should follow this procedure as early as possible in the semester.
Counseling and Student Health
Students may occasionally have personal issues that arise in the course of pursuing higher education or that may interfere with their academic performance. If you find yourself facing problems affecting your coursework, you are encouraged to talk with an instructor and to seek confidential assistance at the UF Counseling & Wellness Center, 352-392-1575. Visit their web site for more information: (http://www.counseling.ufl.edu/cwc/, see also link therein for Emergency Assistance). Crisis intervention is always available 24/7 from the Alachua County Crisis Center at (352) 264-6789. Do not wait until you reach a crisis to come in and talk with us. We have helped many students through stressful situations impacting their academic performance. You are not alone, so do not be afraid to ask for assistance.